Imaging for early stage breast cancer

Second Cancer by Time since Treatment

RT 23,627

Non-RT 22,549

Person years

Solid Second Cancers

OBS

HR (95% CI)

OBS Person years

RT-associated sites

years latency years latency years latency years latency

5-9 1-4 10-14

183,490 20,661 57,926 71,902 33,001

66 69 52

1.00 (0.86-1.16) 1.13 (0.97-1.32) 1.16 (0.95-1.42) 1.04 (0.79-1.37) 1.10 (1.01-1.21) 1.05 (0.89-1.25) 1.11 (0.93-1.32) 1.02 (0.81-1.31) 0.76 (0.53-1.09) 1.04 (0.94-1.16) 0.81 (0.58-1.14) 1.20 (0.86-1.69) 1.55 (1.08-2.24) 1.79 (1.14-2.81) 1.34 (1.11-1.61)

130,765 7,273 39,034 68,678 15,780

328 56 94 100 78

All ≥ 15

226 39

Non RT-associated sites

702 45 237 318 102 928 84 303 397 154

years latency years latency years latency years latency

353 361 228

5-9 1-4 10-14

1,102 106

All ≥ 15

All sites

years latency years latency years latency years latency

447 461 306

5-9 1-4 10-14

1,430 216

All ≥ 15

Grantzau et al. Radiotherapy and Oncology 2013; 106: 42-49

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