Imaging for early stage breast cancer

Dose Response relation of Second Lung cancer after Radiotherapy for Breast Cancer; Treatment lag ≥ 5 years

Fit: Dose used as a continuous variable

▪

Nested case-control study on irradiated breast cancer patients (151 cases and 443 matched controls)

▪

The Rate of Second Lung cancer xxx increased linearly with 8.5% per Gray xxx (95% CI = 3.1% to 23.3%; p<0.001) xxx Indicating that any dose reduction xxx would result in a decreased risk ▪ No better fit using a linear quadratic model (p = 0.36)

Radiation dose in Gy

Grantzau et al. Radiotherapy and Oncology 2014; June Epub ahead of print