Imaging for early stage breast cancer

Meta-analysis on second cancers after Radiotherapy for Breast Cancer: 762,468 Breast Cancer Patients

Inclusion: Cohort studies that compared irradiated early breast cancer patients with un- irradiated patients. Outcome: Studies had to report risk estimates of second cancer; either as the RR or HR together with the corresponding 95% CI. Meta-analysis based on random effects models; to allow for between study variation. Data Source: • 9 population based cohort studies • 3 single institution cohort studies • 1 regional prospective study Region: The study population comprised European or North American populations of female breast cancer patients Study population 13 included studies • Cumulative size: 1,661,193 women • Eliminating overlapping cohorts: 762,468

• RT treated: 321,325 (42%) • Non RT treated: 441,325 (58%)

Grantzau & Overgaard, R&O 2016