Imaging for early stage breast cancer

Endpoint: All Second Non-Breast Cancers

7 299,883 14,472

Overall number of studies: Total number of Patients: All second cancers: Treatment years: Range of FU:

RT 44% NON-RT 56%

1954 to 2007 0 to 37 years

Studies, number of pt.

Relative Risk (95% CI) IV Random

ES RR (95 CI%); Weight %

1.30 (0.95-1.79) 1.50 (1.06-2.12) 1.35 (0.51-3.59) 2.01 (1.16-3.48) 1.40 (1.12-1.75) 1.00 (0.91-1.10) 1.10 (1.00-1.10)

12 11

Andersson 1991

(2,692) (4,416)

Rubino 2000

Rutqvist 2006, Premeopausal Rutqvist 2006, Postmeopausal

(679) (547)

2 5

(46,176) (43,390) (14,678)

17 26 27

Schaapveld 2008, <50 y Schaapveld 2008, >50 y Grantzau 2012

Latency ≥ 5 years TOTAL; I 2 = 66%

1.22 (1.06-1.41) 100

1.11 (1.06-1.16)

76

Berrington d Gonzalez, 2010 (192,057)

1.13 (1.01-1.27) 22 1.12 (1.06-1.19) 100 1.70 (0.98-2.94) 2

Zhang 2011

(NR)

TOTAL; I 2 = 15% Grantzau 2012

(26,598)

RT increased risk

RT decreased risk

0.5

1

2

4