Imaging for early stage breast cancer

Endpoint: Second Esophagus Cancer Overall RR

Overall number of studies: Total number of Patients: Second Esophagus cancers: Treatment years: Range of FU:

4 413,650 386 1961 to 2007 0.6 to 26 years

RT 39% NON-RT 61%

RR ES (95 CI%); Weight %

Studies, number of pt.

Relative Risk (95% CI) IV Random

1.23 (0.75-2.01) 1.86 (1.11-3.11) 0.93 (0.46-1.87) 0.64 (0.16-2.48) 0.85 (0.49-1.48)

25 24 14

(61,782) (14,678) (43,390) (46,176) (61,442) (183,182)

Roychounduri 2004 Zablotska 2005, Mastectomy Zablotska 2005, BCS

4

Schaapveld 2008, >50 y Schaapveld 2008, <50 y

21

Grantzau 2012 TOTAL; I 2 = 11%

1.17 (0.56-2.44)

13

1.17 (0.89-1.54) 100

4

0.5

1

2

RT decreased risk

RT increased risk