Imaging for early stage breast cancer

Endpoint: Second Esophagus Cancer by time since BC diagnosis

Latency period

Relative Risk (95% CI) IV Random

RR ES (95 CI%); Weight %

Latency ≥ 5 years

1.19 (0.60-2.35) 2.21 (1.42-3.45) 0.91 (0.37-2.25) 1.46 (0.57-3.76) 16 1.53 (1.01-2.31) 100 26 42 17

Roychounduri 2004 Zablotska 2005, Mastectomy Zablotska 2005, BCS Grantzau 2012 TOTAL; I 2 = 30% Roychounduri 2004 Zablotska 2005, Mastectomy Zablotska 2005, BCS Grantzau 2012 TOTAL; I 2 = 0%

Latency ≥ 10 years

1.48 (0.62-3.53)

55 10 23

1.81 (1.03-3.19) 0.64 (0.17-2.39) 1.89 (0.57-6.30) 12 1.56 (1.03-2.38) 100

Latency ≥ 15 years TOTAL; I 2 = 0% Grantzau 2012 Roychounduri 2004

2.19 (1.07-4.49) 87 2.07 (0.32-13.39) 13 2.17 (1.11-4.25) 100

0.5

1

4

2

RT decreased risk

RT increased risk