Imaging for early stage breast cancer

Endpoint: Second Thyroid Cancer Overall RR

Overall number of studies: Total number of Patients: Second Thyroid cancers: Treatment years: Range of FU:

4 322,461 188 1961 to 2007 0.2 to 26 years

RT 37% NON-RT 63%

Relative Risk (95% CI) IV Random

Studies, number of pt.

RR ES (95 CI%); Weight %

(194,798)

Huang 2001

1.00 (0.66-1.51)

56

1.32 (0.49-3.57)

9

Roychounduri 2004 Kirova 2007

(61,442)

1.33 (0.39-4.53)

6

(16,705)

(46,176)

1.03 (0.58-1.82) 29 1.05 (0.78-1.43) 100

Grantzau 2012

TOTAL; I 2 = 0%

1

2

4

0.5

RT decreased risk

RT increased risk