Imaging for early stage breast cancer

Endpoint: Second Thyroid cancer by time since BC diagnosis

RR ES (95 CI%); Weight %

Relative Risk (95% CI) IV Random

Latency period

Latency ≥ 5 years

0.81 (0.44-1.50)

63

Huang 2001

Roychounduri 2004

0.96 (0.59-1.57) 100 1.49 (0.48-4.63) 18 1.11 (0.36-3.43) 19

Grantzau 2012

TOTAL; I 2 = 0%

Huang 2001 Roychounduri 2004 Grantzau 2012 TOTAL; I 2 = 0% Latency ≥ 10 years

1.37 (0.50-3.75) 2.57 (0.45-14.74)

62 21

1.25 (0.19-18.34) 17 1.53 (0.69-3.39) 100

Latency ≥ 15 years

2.56 (0.32-20.50) 1.70 (0.18-16.04)

35 30

Huang 2001

Roychounduri 2004 Grantzau 2012 TOTAL; I 2 = 0%

2.21 (0.64-7.61) 100 2.39 (0.29-19.82) 34

0.5 1 2 4

RT increased risk

RT decreased risk