Imaging for early stage breast cancer

Endpoint: Second Sarcomas

Overall number of studies: Total number of Patients:

5 684,104 1,048

RT 41% NON-RT 59%

Second Sarcomas: Treatment years: Range of FU:

1973 to 2007 1 to 26 years

Studies, number of pt.

Relative Risk (95% CI) IV Random

RR ES (95 CI%); Weight %

7.46 (1.02-54.54)

6

Schaapveld 2008, <50 y Schaapveld 2008, >50 y Kirova 2007 Mery 2009, incl. DCIS

(46,176) (563,155) (43,390) (14,678) (16,705)

2.82 (0.34-23.34) 3.43 (1.46-8.05) 1.54 (1.31-1.81) 2.96 (1.29-6.80)

6

21 45 22

Grantzau 2012 TOTAL; I 2 = 49%

2.41 (1.41-4.13) 100

Grantzau 2012 Berrington d Gonzalez, 2010 (192,057) Latency ≥ 5 years (26,598) TOTAL; I 2 = 0%

2.52 (1.67-3.81) 2.61 (1.02-6.68)

84 16

2.53 (1.74-3.70) 100

1 2 4 5

0.5

RT decreased risk

RT increased risk