Imaging for early stage breast cancer

Endpoint: Second Lung Cancer Overall RR

Overall number of studies: Total number of Patients: Second Lung cancers: Treatment years: Range of FU:

7 631,021 4,016 1961 to 2007 0.2 to 26 years

RT 40% NON-RT 60%

RR ES (95 CI%); Weight %

Studies, number of pt.

Relative Risk (95% CI) IV Random

Zablotska 2005, Mastectomy (194,981) Andersson 1991 (2,692)

1.10 (0.31-3.86)

1

1.33 (1.08-1.64)

20

(46,176) (43,390) (14,678) (61,442) (65,560) (16,705)

Zablotska 2005 , BCS Roychounduri 2004 Schaapveld 2008, <50 y Schaapveld 2008, >50 y Grantzau 2012 Kirova 2007

1.07 (0.85-1.34) 1.28 (1.03-1.59)

18 19

3.09 (1.12-8.53)

2

2.31 (1.16-4.62)

4

0.94 (0.72-1.22)

16

1.27 (1.04-1.55)

20

TOTAL; I 2 = 44%

1.23 (1.07-1.43) 100

0.5

1

2

4

RT decreased risk

RT increased risk