Imaging for early stage breast cancer

Endpoint: Second Lung Cancer by time since BC diagnosis

Latency period

Relative Risk (95% CI) IV Random

RR ES (95 CI%); Weight %

Latency ≥ 5 years

1.36 (1.07-1.72)

11

Roychounduri 2004

1.38 (1.26-1.51)

77

Grantzau 2012 Berrington d Gonzalez, 2010 TOTAL; I 2 = 0%

1.49 (1.19-1.87)

12

1.39 (1.28-1.51) 100

Latency ≥ 10 years

1.62 (1.36-1.93) 1.07 (0.48-2.39) 1.54 (1.17-2.03)

56

Zablotska 2005, BCS Zablotska 2005 , Mastectomy

3

23

Roychounduri 2004

1.63 (1.20-2.21)

19

Grantzau 2012

TOTAL; I 2 = 0%

1.59 (1.39-1.81) 100

Roychounduri 2004 Grantzau 2012 Zablotska 2005 , Mastectomy Latency ≥ 15 years

1.67 (1.28-2.18) 1.49 (1.04-2.13) 1.94 (1.21-3.12)

53 30 17

TOTAL; I 2 = 0%

1.66 (1.36-2.01) 100

2

4

0.5

1

RT increased risk

RT decreased risk