Imaging for early stage breast cancer

Group of second cancers at high dose sites:Esophagus, pleura, lung, bones & connective tissues. Latency 5 years following BC diagnosis, by surgery type

RR ES (95 CI%); Weight %

Surgery type

Relative Risk (95% CI) IV Random

69,296 / 112,761 RT / Non-RT 12,104 / 14,494

Mastectomy & BCS

1.45 (1.33-1.58) 1.54 (1.24-1.91) 14 1.46 (1.35-1.58) 100 86

Grantzau 2012 Berrington d Gonzalez, 2010

TOTAL; I 2 = 0%

BCS

1.28 (1.14-1.43) 1.35 (1.04-1.75) 16 1.29 (1.16-1.43) 100 84

Grantzau 2012 Berrington d Gonzalez, 2010

50,278 / 112,761 4,416 / 5,632

TOTAL; I 2 = 0%

Mastectomy

1.50 (1.23-1.83) 1.74 (1.48-2.04) 59 1.64 (1.42-1.89) 100 41

Grantzau 2012 Berrington d Gonzalez, 2010

19,018 / 112,761 3,041 / 5,632

TOTAL; I 2 = 23%

2

1

4

RT decreased risk

RT increased risk