Imaging for early stage breast cancer

PAPBI study, preoperative accelerated partial breast irradiation Randomised phase III trial

Randomisation preop APBI versus standard adj RT Inclusion: >50 yr, T≤3 cm, unifokal on mammogram and MRI, cN0, invasive ductal carcinoma grade 1-2 on biopsy Primary endpoint: 3 year cosmesis Start Febr 2017 in NKI, Amsterdam, by Nov 2018 25 pts accrued N=500 patients PI: Astrid Scholten, NKI

Partial Breast RT pre-operatively 5 x 5.7 Gy Surgery at 6 weeks after RT