Imaging for early stage breast cancer

Randomized APBI studies using 3D CRT according to ClinicalTrials.gov

Name Endpoint

N Start - end

Standard arm, WBI

APBI arm

Principal Investigator

NSABP B39/RTOG 0413, USA

IBTR

4216 2005- 2013

Normofractionated 5-6 weeks

RT bid using 3D CRT, MammoSite; IBT

Norman Wolmark

RAPID

IBTR

2135 2006- 2011

50 Gy / 25 fr or

38.5 Gy / 10 fr / 5 days

Ivo Olivotto, Tim Whelan

Canada

42.5 Gy / 16 fr

IMPORT LOW

IBTR

1935 2006- 2010

40 Gy / 15 fr

Arm 1: 40Gy/36Gy / 15 fr

John Yarnold

England

Arm 2:40 Gy / 15 fr

Livi, Italy

IBTR

520 2005- 2014

50 Gy / 25 fr

30 Gy / 5 fr / Overall treatment time unknown

Lorenzo Livi

IRMA

IBTR

3302 2007 50 Gy / 25 fr

38.5 Gy / 10 fr / 5 days

Giovanni Frezza

Europe

SHARE

IBTR

2796 2010 50 + 16 Gy boost or 40 Gy / 15 fr or 42.5 Gy / 16 fr

38.5 Gy / 10 fr / 5 days or 40 Gy / 10 fr / 5 days

Y.Belkacemi E. Lartigau C. Bougier

France

DBCG PBI

Grade 2/3 fibrosis

882 2009- 2016

40 Gy / 15 fr

40 Gy / 15 fr

Birgitte Offersen

Denmark

2009-APBI

Breast pain 660 2009 No standard arm

38.5 Gy / 10 fr / 5 days in both arms.

Charles Leonard

Colorado

R is IMRT vs 3D CRT

-and several other trials using other techniques for APBI