Lower GI 2017

The Royal Marsden

Secondary endpoints

1. 2. 3. 4. 5. 6. 7. 8. 9.

Time to local re-growth.

Time to maximal tumour response after CRT Time to local pelvic relapse, pre or post surgery. Time to metastatic relapse, pre or post surgery.

Percentages of positive margins, and sphincter-preservation rates in patients who have had surgery. Pathology T N stage.

Progression-free and overall survival

Quality of Life including long-term bowel and urinary function

Probability of detecting early re-growth on MRI at 16 weeks, 24 weeks and 9 months. Report on proportion of patients eligible at 12 weeks compared to eligible at 6 weeks. Frequency of local re-growth detected outside scheduled imaging/endoscopic timepoint by DRE/CEA.

10.