Lower GI 2017

Prognostic Value of TRG after CRT for Rectal Cancer : CAO/ARO/AIO-94 TRIAL

* p = 0.33 ** p = 0.009 *** p = 0.006

N Node pos 5yr LR 5yr met free Survival

5yr DFS

TRG 0 + 1 75 41% 6% 66% 63%

TRG 0: no regression

TRG 1: fibrosis < 25% tumor mass TRG 2: fibrosis 25-50% tumor mass TRG 3: fibrosis > 50% tumor mass TRG 4: complete regression

TRG 2 + 3 229 32% 4% 75% 75%

TRG 4

40 10% 0%* 86%**

86%**

ypT & ypN stage still most important prognostic factors for DFS on multivariate analysis !

Rodel et al 2005