Lower GI 2017

CAO/ARO/AIO-94 Trial

N = 386 Median F.U. 132 months

TRG % 10 yr

10 yr DFS

DM rate

TRG 0+1 23.3% 39.6% 63% TRG 2+3 66.3% 29.3% 73.6% TRG 4 10.4% 10.5% 89.5%

HR for TRG in multivariate analysis :

0.74 for DM 0.76 for DFS

p < 0.04

( Fokas et al 2014 )