Lower GI 2017

Locally advanced Rectal Cancer (LARC) 2:

• However, only 10-25% achieve a pathological CR or CCR after definitive CRT

• Approx 30-40% of patients fail to respond

• Most patients will not achieve sustained local control unless surgery is added.

• Despite low dose - considerable late morbidity

• Late morbidity is contributed to (but not usually caused) by surgery.