Lower GI 2017

Mid eighties first phase III trials

Arm A Arm B US (RTOG 8704) XRT+ 5 FU XRT + 5 FU-Mito C EORTC 22861 XRT XRT + 5 FU-Mito C

UKCCCR ACT I XRT

XRT + 5 FU-Mito C

US (RTOG-8704)

XRT+ 5 FU XRT + 5 FU-MMC p value

Complete response Colostomy- free survival 59%

86% 22% 51% 71%

92,2% 71% 9% 73% 78,1%

0,014 0,002

Colostomy rate

DFS OS

0,31

4