Lower GI 2017

EORTC 22861 XRT

XRT + 5 FU-MMC p value

Complete response Local Failure rate (5 years) 50% 54%

80% 32%

0,02 0,03 0,17

Colostomy free survival Increase by 32% (see graph)

DFS (5 years)

Estimated improvement by 18%

OS

54%

58%

Colostomy-free survival

ACT-I

• RT

45Gy/20-25 fractions

• CRT

(5FU 2 x 4d. Mito 12 mg/m)

After 6 weeks boost: • Irdidium implant to 25Gy (10Gy/d.) or • External beam irradiation: 15Gy in 6 fractions

Northover, Br J Cancer 2010

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