Molecular Imaging 2017

Analysis of tumor heterogeneity

Houweling A et al. Radiother Oncol 2013;106(2):250-4.

N=18 HNC patients

•

• Examined with FDG PET and DW-MRI • Voxel-based correlation of ADC values and FD uptake • Comparison of ADC- and FDG-based volumes for potential RT dose escalation

SUV

Positive Spearman correlation,

max FDG and ADC may identify different volumes for dose painting. This may have severe consequences on the resulting dose distribution!

Low mutual information

SUV

ADC

SUV

min

ADC

ADC

min

max