Molecular Imaging 2017

DWI and treatment response of GBM

• Most studies evaluate ADC values within regions of abnormal T2/FLAIR or contrast enhancmeent – Increase in normalized ADC post RT : consistent with treatment response Li et al, neurooncol 2011 – Tumor progression exhibits lower ADC values post RT compared with stable disease Lutz et al JMRI 2013 – ADC changes may have prognostic impliations in patients treated with bevacizumab ( significant alterations in CE) Pope AJN2011

• Study in 27 patients of isolated ADC hypointensity without corresponding CE -> in 85% of the cases CE developed at the site of ADC hypointensity

Gupta et al AJN 2011