Particle Therapy 2017

XRCC DNA- pol

PARP

Ligase

poly (ADP-ribosylation)

PARP recognizes both DNA repair: Non-homologeous endjoining (NHEJ) Double Strand Break (DBS) single and double strand breaks. PARP causes poly (ADP- ribosylation) to enhance access to DNA single

strand repair proteins

such as XRCCI, Ligase III and DNA polymerase .