Particle Therapy 2017

Ligase

Ku70 Ku70 Ku80 Ku80

assists in repairing the break XRCC

DNA-PK

DNA repair: Non-homologeous endjoining (NHEJ) Double Strand Break (DBS) Fast repair, can be error-prone !!!

Exposed ends of the DNA strands are detected by the KU70–KU80 heterodimer DNA-dependent protein kinase ( DNA-PKcs ) stabilize broken ends The heterodimer XRCC4/Ligase IV subsequently Loss of complete possible

sequences of bases