Particle Therapy 2017

Hypoxia in solid tumors

human squamous cell carcinomas of the oropharynx

Bussink et al. Radiother Oncol, 67: 2003

Blood vessels ( blue ), exogenous hypoxia marker (pimonidazole, green ) and endogenous hypoxia marker (carbonic anhydrase 9, red ) Arrows indicate areas with almost no pimonidazole staining but extensive expression of CA9. CA9 expression is also often found closer to vessels than pimonidazole, indicating that CA9 is expressed at higher pO2 levels (magnification 100 x)