Particle Therapy 2017

Aim 1: Insight into Biologic Mechanisms

● Specific Aim 1: To determine the early changes in multiple biomarkers in patients undergoing RT, and how these changes differ in proton versus photon therapy. Hypothesis: Early increases in circulating biomarkers will differ according to RT; photon therapy will result in a more adverse biomarker profile.

Biologic Alteration

Biomarker

Inflammation

GDF-15, hsCRP

Microvascular Dysfunction PlGF Oxidative Stress

MPO, PON, Aryl

Myocyte Injury Myocyte Stress

TnT

NT-proBNP Galectin-3

Fibrosis

RADCOMP CONSORTIUM

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