Particle Therapy 2017

Aim 2: Insight into Functional Changes ● Specific Aim 2: To determine the early changes in sensitive echo-derived measures in patients undergoing RT, and how these changes differ in proton versus photon therapy. Hypothesis: Early abnormalities in measures of cardiac size, function and mechanics will differ according to RT; photon therapy will result in worse remodeling. Functional Alteration Echocardiographic Measure Ventricular Structure LV and RV size and mass Systolic Function LV and RV Strain, Strain rate, Ejection fraction Diastolic Function e/a, e’, a’ Ventricular/Vascular Stiffness Ea, Ees, Ea/Ees Systolic/Diastolic Deformation Twist, Torsion

RADCOMP CONSORTIUM

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