Physics Bucharest 2017

Clinical studies

Study (year)

n

Dose

Adaptive strategy Target coverage Normal tissue sparing

55Gy in 20f (bladder) (40Gy in 20f pelvis) or 60Gy in 25f (tumour, 6 patients)

3DCRT composite from week 3, for 10-25f

Pos et al., (2006)

5% repeat CT scan GTV not covered by PTV

40% reduction in PTV

21

185cm 3 high dose volume reduction (plan of the day) and 220cm 3 (composite) compared to conventional margin approach Bowel V45Gy improved by 155cm 3 compared to conventional margin 210cm 3 volume reduction in tissue receiving 95% dose compared to conventional margin approach

3DCRT 3 phase sequential delivery (adaptive phase 3 plan of the day or composite) IMRT 2 phase sequential delivery Plan of the day, phase 1, 3-4 plans; phase 2, 2-4 plans

Huddart et al., (2011)

64-68Gy in 32-34f (tumour) 50Gy in 25f (bladder)

*V95 98% (plan of the day), 91% (composite)

26

45-50.4 Gy in 25-28f (bladder) followed by 10-20Gy in 5-10f (tumour)

Tuomikoski et al., (2011)

V95<100% 3% (4/121 fractions)

5

McDonald et al., (2011)

3DCRT Plan of the day, 3 plans

25

36Gy in 6f (bladder)

*V95 99%

49