Physics Bucharest 2017

29% reduction in tissue receiving >45Gy compared to conventional approach

Foroudi et al., (2011)

3DCRT, Plan of the day, 3 plans for 8-32f IMRT Plan of the day, 6 plans

V95< 99% in 2.7%

27

64Gy in 32f (bladder)

Meijer et al., (2012)

>95% appropriately fractions covered 18.4% patients target at least once (5.5% f) outside PTV as assessed on post RT CBCT

20 59.8Gy in 23f (tumour) 46Gy in 23f (bladder)

Foroudi et al., (2014)

3DCRT Plan of the day, 3 plans for 8-32f

54

64Gy in 32f (bladder)

30% (185cm 3 ) reduction in adaptive PTV, bowel V45Gy

IMRT (VMAT) Plan of the day, 3 plans for 6-30f

Vestergaard et al., (2014)

improved by 100cm 3 and rectal V30 improved by 10%

60Gy in 30f (bladder) 48Gy in 30f to (pelvic LN)

20

compared to non-adaptive approach

IMRT (tomotherapy) Plan of the day, 3 or 6 plans IMRT Plan of the day, 3 plans

Murthy et al., (2016)

68Gy in 32f (tumour) 64Gy in 32f (bladder) 55Gy in 32f (pelvic LN) 70Gy in 32f (tumour) 52Gy in 32f (bladder)

44

Hafeez et al., (2016)

D98 > 97% (post treatment CBCT)

20

50