Physics Bucharest 2017

HYBRID study of hypofractionated Bladder Radiotherapy with or without Image guided aDaptive planning

A multicentre randomised phase II study

RANDOMISE 1:1

Group 1: Standard planning (control)

Group 2: Adaptive planning (experimental)

Planning CT scan post void. Clinical target volume (CTV): whole bladder plus any area of extravesical spread. One 3D conformal plan will be generated with 1.5cm expansion margin.

Planning CT scan post void. CTV: whole bladder plus any area of extravesical spread.

Three 3D conformal plans will be generated: 1. Small; 2. Medium; 3. Large

Pre-treatment Cone Beam CT will be used to verify CTV coverage.

Pre-treatment Cone Beam CT will be used to select appropriate plan, this will be confirmed by a second trained observer.

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