Quality Management 2017

Action limits - Proposed philosophy

Step 3: Adjust the true dose probability distribution such that the dose limits IDC-C  /2 and IDC+C  /2 coincide with the clinical tolerance limits.

Prescribed dose

Probability distribution for the true dose

Dose (Gy)

TL

is set to a minimum acceptable cure rate

TL

is set to a maximum acceptable complication rate

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Clinical tolerance limits