Quantitative Methods 2017

Step 4: Clinical validation study Identical prospective data collection

After completion of radiotherapy

Weekly during RT

Assessment

T0

6 wks

6 mos

12 mos

18 mos

è 60 mos

Acute toxicity

+ + +

+

+ + + +

Late toxicity

+ + + + + +

PROMs

yearly

Analytic endpoints

+

+ +