Quantitative Methods 2017

Step 4: Clinical validation study Study design

Standard IMRT plan

1. Spare parotid glands 2. NO dose constraints for SWOARs 3. Estimate NTCP for grade II-IV Dysphagia = NTCP standard IMRT 4. Save and store (BACK UP plan)

SW-IMRT plan

1. Similar dose to parotid glands 2. Spare SWOARs 3. Estimate NTCP for grade II-IV Dysphagia = NTCP SW-IMRT

Treat with SW-IMRT

4. Calculate expected ΔNTCP = NTCP standard IMRT – NTCP SW-IMRT