Quantitative Methods 2017

Indication protocol Head and neck cancer

Endpoint

Source ∆NTCP Level of evidence

Moderate-to severe xerostomia (patient-rated EORTC QLQ-HN35)

Beetz 2012 ≥ 10% Level 3

Christianen 2012

Dysphagia grade ≥ II (CTCAE)

≥ 10% Level 3

Tube feeding dependence

Wopken 2014 ≥ 5% Level 3

External validation in new dataset from UMCG. Analysis performed by independent party: The Health Innovation Center (THINC)