Quantitative Methods 2017

Model-based approach Rapid Learning Health Care (RLHC) system

‘Validation train’ approach: 1. No change 2. Recalibration intercept 3.

Most relevant dose Volume factors

Multivariable NTCP model Model-based validation NTCP-mod l improvement

Recalibration intercept and slope

4.

Refit

IMPT dose optimisation

IMRT dose optimisation

Prospective data registration

IMPT protons IMRT photons

∆NTCP- profile