Radiobiology 2016

1/03/2016

Take home messages

• Late-responding tissues • Partial (CNS, lung) or complete (skin) restoration of tolerance after low to moderate doses (<60% initial tolerance) • Progression of damage at subclinical level (kidney, urinary bladder) must be expected thus precluding re- irradiation without exceeding tolerance

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Take home messages

• Strategies for retreatment • Alternative treatment options must be considered before re-irradiation • If (curative) re-irradiation is to be considered • Use best available treatment planning • Consider hyperfractionation for treatment with curative intent • Consider combined EBRT and brachytherapy

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