Research Masterclass in Radiotherapy Physics 2017
Overcoming organ-based approach of dose-volume modelling
Organ-based…an intuitive and natural way to describe radiotherapy-induced effects Organs as «independent and homogeneous entities» is a robust and practically usable approximation for most end-points Supported the translation from «qualitative» to «quantitative» RT ….knowledge condensed into organ constraints/EUDs/NTCPs Successful in reducing toxicities by guiding RT to «safely» deliver treatments respecting organ-based constraints Conserving a «flavour» of Radiobiology (....serial and parallel-like organs…) «Easy» incorporation in multi-variable phenomenological models
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