Research Masterclass in Radiotherapy Physics 2017
Overcoming organ-based approach of dose-volume modelling
Cella et al. PlosOne2014, Complication Probability Models for Radiation-Induced Heart Valvular Dysfunction: Do Heart-Lung Interactions Play a Role?.
The organ-based DVH approach is clearly a (useful) “hard constraint” not reflecting the real world in many situations: 1) Symptoms may depend on the dose received by multiple organs 2) Organs are not “homogenous entities” from the point of view of their response to radiation and their functions
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