SBRT2015

Median OS

LRC/OS 2 ans

n

Treatment

Toxicity

13% acute 12% late 3% bleeding

De Crevoisier 1998

66 Gy / OHurea-5FU 60 Gy/ CDDP-5FU-myto

169

10 m 11% / 21%

Kramer 2005

60 Gy / CDDP-paclitaxel

16% acute 29% late

38

12,4 m 37% / 35%

Salama 2006

66-74 Gy / 3 agents de CT

13% late 5% bleeeding

66

11 m 36% / 11%

Lee 2007

60 Gy 70% IMRT 70% CT conco

69

4% neuro

15 m 19% / 12%

Langer 2007

60 Gy / CDDP-paclitaxel

99

28% acutes, 9% DC

12,1 m

19% / 26%

Spencer 2008

81

60 Gy / OHurea-5FU

23% acutes

8,2 m NR / 16%

Sulman 2009

66 Gy 100% IMRT 66% CT conco

54

32%acute

25,2 m 58% / 54%