Target Volume Determination 2015

Enhancing lesion post radiotherapy

Visions

MRSI in brain lesions: Summary

Cho

Lipids

Pathology

Cho/Cr Cho/Cho(n) NAA/Cr

Cho peritumoral

Lipide

⇑⇑

⇑⇑

⇑

High grade glioma

⇓ ⇓

NAA

NAA

⇑

⇑

⇓

Low grade glioma

~

⇓

⇓

⇓

⇓

Radiation necrosis

⇑

⇑

⇓

Metastasis

⇓ ⇓

0.5 ppm

0.5 ppm

4.0

3.5

3.0

2.5

2.0

1.5

1.0

4.0

3.5

3.0

2.5

2.0

1.5

1.0

Radiation damage

Tumor progression

⇑

⇑

⇓

Lymphoma

⇓ ⇓

Law 2004

23 Na Imaging

Sodium imaging

1,5 T

3 T

7 T

• Possible applications: – Viability – Therapy monitoring

Positron emission tomography

Courtesy of M.A. Weber and M. Bock, Heidelberg