Target Volume Determination 2015

PET isotopes

PET tracers - oncology

Gamma decay

• Metabolism – 18 FDG • Amino acids

• Perfusion – H 2 15 O • Proliferation – 11 C-thymidine – 18 FLT

Isotope

T 1/2

(min)

E max

(MeV)

11 C 13 N 15 O

20,4

0,97 1,19 1,72 0,64

– 11 C-methionine – 18 F-tyrosine – 11 C-AIB – 18 FET

9,9

– 18 F-Ethyl Choline – 11 C-Choline

2,05

Positron decay

• Hypoxia

• Peptides

18 F

109

– 18 F-MISO

• Drugs – 18 FU

– 68 Ga-DOTATOC – 68 Ga-PSMA

68 Ga

68

1,9

68Ga-DKFZ-PSMA-11

FDG metabolism

CT/PET hybrid system

Metabolic compartment

Extracellular space

Vascular compartment

Capillarymembrane

Eder M et al. Bioconjugate Chem 2012; 23: 688-697. Afshar-OromiehAet al. Eur J Nucl Med Mol Imaging 2013; 40: 486-495.