Target Volume Determination 2015

Per-treatment target volume changes

Per-treatment GTV (PET) volume changes (observational studies)

Per-treatment imaging/autosegmentation method

Δ per-treatment volume/ pretreatment volume GTV-T Week 2,3,4,5: -3.9%/day

Radiotherapy technique

Reference

Castadot 2010

IMRT

FDG-PET/ gradient-based

GTV-T Week 2: -4% Week 4: +19%

Troost 2010

IMRT

FLT-PET/ signal-to-background ratio

Hentschel 2009

3D-CRT

GTV FDG-PET/ signal-to-background ratio

GTV sum Week 1/2: +33% Week 3/4: +51% Week 5/6: +92%

GTV

CTV

CTV

PTV

PTV

Castadot et al. Radiother Oncol 2010;95:209-17. Troost et al. J Nucl Med 2010;51:866-74. Hentschel et al. Int J Radiat Biol 2009;85:796-804.