Target Volume Determination 2015

Optic nerve tolerance & risk

Stupp trial (Ataman EJC 2004)

The recommended maximum doses were below 55 Gy for the optic chiasm (and brainstem)

In QA on 53 cases; optic chiasm dose known in 48

Max dose > 55 Gy in 10/48 cases (i.e. ~ 20%)

Ataman Eur J Cancer 2004: 40: 1724-1730