Target Volume Determination 2015

Optic nerve tolerance & risk

Stupp 2009 - risk with 55/60 Gy + TMZ

1 patient affected ~ 20% - dose assumed to be 60 Gy ~ 200 alive at risk at 9 months ~ 100 alive at risk at 2 years ~ 20 pts at risk

Therefore risk* ~ 1 in 20 = 5%

But 17pts alive @ 5 years