paediatrics Brussels 17

Principle of Benefit

From first principles, it would follow that the largest benefit for protons will be in the youngest patients (at risk for late RT effects for the longest period of time) with potentially curative (either localised or oligometastatic) tumours, requiring RT to large target volumes (where a larger normal tissue volume would be spared exit dose) or to a large proportion of a critical organ (i.e. eye, liver, and spinal cord) to high RT doses .

T. Delaney & R. Haas, 2016