paediatrics Brussels 17

PT and SMN

Lower integral dose with protons could also reduce the risk of RT associated secondary malignancies. • Chung et al. 2013 : compared 558 proton patients with 558 matched patients (mainly adults), med. FU 6.7. and 6.0 years. On multi- variable analysis, PRT was associated with a decreased risk of SMN [adjusted hazard ratio, 0.52, p = 0.009] • Sethi et al. 2014: SMN among patients treated PT or XRT for RB, med. FU 6.9 for PT/ 13.1 years for XRT, the 10-year cumulative incidence of RT-induced SMN was significantly less among the proton cohort (0 vs. 14%, p = 0.015)