paediatrics Brussels 17

Treatment of Posterior Fossa Ependymoma Subgroups

A

B

1.00

1.00

0.75

0.75

0.50

0.50

OS (probability)

0.25 PFS (probability)

0.25

EPN_PFA EPN_PFB

EPN_PFA EPN_PFB

P = .00141

P < .001

0

1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

0

1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

EPN_PFA EPN_PFB No. at risk

EPN_PFA EPN_PFB No. at risk

54 48 36 30 25 23 23 20 17 13 7 130 116 104 91 77 69 58 46 38 28 22

54 51 42 38 33 29 28 24 21 16 10 130 120 111 99 84 76 64 52 43 32 24

Fig A4. Survival by subgroup in patients with an age at diagnosis of greater than 10 years for (A) progression-free survival (PFS) and (B) overall survival (OS).

A

B

1.00

1.00

0.75

0.75

0.50

0.50

0.25 OS (probability)

Female/GTR Male/GTR Female/STR Male/STR

Female/GTR Male/GTR Female/STR Male/STR

0.25 PFS (probability)

P < .001

P < .001

0

1 2 3 4 5 6 7 8 9 10 Follow-Up Time (years)

0

1 2 3 4 5 6 7 8 9 10 PFS (years)

Male/STR No. at risk

Male/STR No. at risk

176 162 144 130 113 105 83 73 61 48 37 248 225 194 159 133 116 103 87 64 53 43 95 80 71 58 49 40 30 23 16 11 8 140 118 100 77 63 44 35 24 22 19 14

176 149 124 105 92 86 68 58 47 37 29 248 204 150 118 97 84 76 63 46 38 33 95 66 51 40 31 28 23 17 13 10 6 140 100 72 50 36 28 18 15 14 11 10

Female/GTR Male/GTR Female/STR

Female/GTR Male/GTR Female/STR

Fig A5. Sex as a function of extent of resection in EPN_PFA for (A) progression-free survival (PFS) and (B) overall survival (OS). P values were determined using the log-rank test. GTR, gross total resection; STR, subtotal resection.

© 2016 by American Society of Clinical Oncology

www.jco.org

from 139.18.224.1 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016 Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.