paediatrics Brussels 17

Ramaswamy et al

A

B

STR

GTR

1.00

1.00

0.75

0.75

GENE Cohort

0.50

0.50

0.25

0.25

OS (probability)

OS (probability)

No first-line XRT First-line XRT

No first-line XRT First-line XRT

P < .001

P = .003

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

39 26 20 15 11 11 11 11 11 8 6 No first-line XRT 137 122 103 86 68 56 43 37 28 21 16 First-line XRT No. at risk

No. at risk

21 7 4 3 3 3 2 2 2 2 2 No first-line XRT 66 51 46 35 31 19 15 11 9 7 5 First-line XRT

C

D

1.00

1.00

0.75

0.75

CERN Cohort

0.50

0.50

0.25

0.25

OS (probability)

OS (probability)

No first-line XRT First-line XRT

No first-line XRT First-line XRT

P = .1

P = .07

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

No. at risk

No. at risk

14 14 12 10 8 7 6 6 6 5 4 35 34 31 29 25 24 18 13 7 4 3

15 14 12 10 10 9 8 6 5 4 3 22 21 18 17 14 12 9 6 4 3 3

No first-line XRT First-line XRT

No first-line XRT First-line XRT

E

F

1.00

1.00

0.75

0.75

Burdenko Cohort

0.50

0.50

0.25

0.25

OS (probability)

OS (probability)

No first-line XRT First-line XRT

No first-line XRT First-line XRT

P = .6

P = .6

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

0 1 2 3 4 5 6 7 8 9 10 Time Since Diagnosis (years)

No. at risk

No. at risk

No first-line XRT First-line XRT

30 26 22 17 13 12 9 9 9 8 6 84 79 66 54 46 37 31 26 10 8 5

27 25 20 16 10 6 3 1 1 0 0 70 63 53 38 31 23 17 10 7 7 5

No first-line XRT First-line XRT

Fig A6. Overall survival (OS) of EPN_PFA for the four cohorts divided by (A, C, and E) gross total resection (GTR) and (B, D, and F) subtotal resection (STR). P values were determined using the log-rank test. CERN, Collaborative Ependymoma Research Network; GENE, Global Ependymoma Network of Excellence; XRT, radiotherapy.

J OURNAL OF C LINICAL O NCOLOGY

© 2016 by American Society of Clinical Oncology

from 139.18.224.1 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on June 20, 2016 Copyright © 2016 American S ciety of Clinical Oncology. All rights reserved.