paediatrics Brussels 17

Medulloblastoma • 20% of paediatric brain tumours • Propensity for leptomeningeal spread • Craniospinal Radiotherapy (CSRT) essential • ~ 30% have evidence of leptomeningeal spread at diagnosis • Radiosensitive (‘radio-curable’) and chemosensitive • Long-term toxicity of treatments problematic, particularly for infants