paediatrics Brussels 17

SIOP 1

• 1975-1979 • 286 patients with medulloblastoma, 45 patients with ependymoma • Randomisation between RT alone and RT followed by VCR/CCNU for 1 year • Overall survival 53% at 5 years, 45% at 10 years • At close of trial survival advantage for chemotherapy (p=0.005), which was later lost owing to late relapses ➢ Tait DM et al, Eur J Cancer 1990; 26: 464-469